![]() Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. The most common adverse reactions (>5%) included transient chromaturia, erythema, oxalate crystals in urine, rash (predominantly acneiform), increased blood pressure, nausea, headache, decreased lymphocyte percentage, and injection site reactions.Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study Safety and effectiveness of CYANOKIT have not been established in pediatric patients. CYANOKIT should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies of CYANOKIT in pregnant women. Due to potential photosensitivity, patients should avoid direct sun until erythema resolves. ![]() Also, because of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a "blood leak." This should be considered before hemodialysis is initiated in patients treated with hydroxocobalamin. Usage may interfere with some clinical laboratory evaluations. Elevations in blood pressure (≥180 mmHg systolic or ≥110 mmHg diastolic) were observed in approximately 18% of healthy subjects receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g. Substantial increases in blood pressure may occur following CYANOKIT therapy. Monitor renal function for 7 days following CYANOKIT therapy. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.Īcute renal failure with acute tubular necrosis, renal impairment, and urine calcium oxalate crystals have been reported following CYANOKIT therapy. Allergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash. Consideration should be given to use of alternative therapies, if available. Use caution in the management of patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin. In addition to CYANOKIT, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of any seizure activity. Prior to administration of CYANOKIT, smoke-inhalation victims should be assessed for: exposure to fire or smoke in an enclosed area presence of soot around the mouth, nose, or oropharynx, and altered mental status. IMPORTANT SAFETY INFORMATION AND INDICATIONĬYANOKIT (hydroxocobalamin for injection) 5 gĬyanide poisoning may result from inhalation, ingestion, or dermal exposure. Once reconstituted, hydroxocobalamin is stableįor up to 6 hours at temperatures not exceeding 40☌ (104☏).Īny reconstituted product not used by 6 hours should be discarded. Freezing/defrosting cycles defined as 15 days subjected Transport in the desert defined as 4 days subjected Usual transport defined as 15 days subjected to In the desert, and freezing/defrosting cycles. To temperature variations of usual transport, transport ĬYANOKIT may be exposed, during short periods, Storage: Lyophilized Form Store at 25☌ (77☏) excursions permitted to 15☌-30☌ One sterile intravenous infusion set one package insert Hydroxocobalamin for injection one sterile transfer spike Kit Contains One 250-mL glass vial containing 5 g lyophilized If clinical suspicion of cyanide poisoning is high, CYANOKIT should be administered without delay.ĭelivers Full starting dose of 5 g of hydroxocobalamin in a single vial diluent for infusion not includedĭimensions W: 194 mm x L: 100 mm x H: 97 mm Treat with CYANOKIT-an FDA-approved treatment option for cyanide poisoning.ĬYANOKIT is indicated for the treatment of known or suspected cyanide poisoning. ![]() If cyanide poisoning is known or suspected, time may be running out.
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